(4-Bromophenyl)hydrazine hydrochloride
4-Bromophenylhydrazine Hydrochloride (CAS 41931-18-4) is an arylhydrazine salt used as a key building block in heterocyclic synthesis. Its most important application is the Fischer indole synthesis, where it condenses with aldehydes or ketones to build indole scaffolds — structural motifs that appear in numerous active pharmaceutical ingredients and functional dyes.
Supplied as the hydrochloride salt, it offers far better handling and storage stability than the free hydrazine base. Typical downstream targets include indoles, indazoles and other nitrogen heterocycles for pharmaceutical R&D, as well as specialty dye intermediates. Every batch ships with COA, TDS, and a GHS-compliant English SDS.
4-Bromophenylhydrazine Hydrochloride (CAS 41931-18-4, C6H8BrClN2) is the hydrochloride salt of an arylhydrazine. Supplying it as the salt rather than the free base is a deliberate advantage: the solid has better handling characteristics, far greater storage stability and reduced oxidation, while liberating the reactive hydrazine in situ once the reaction conditions are set.
The molecule carries two reactive handles that make it a versatile building block: the terminal −NH2 of the hydrazine group and the aryl bromide. The hydrazine group drives condensation chemistry with carbonyl compounds, while the para-bromine provides a clean site for palladium-catalysed cross-coupling when the aromatic ring has to be elaborated later in the route.
Its most important use is the Fischer indole synthesis, where the hydrazine condenses with an aldehyde or ketone and then rearranges to build the indole scaffold. Indoles are one of the most common heterocyclic motifs in active pharmaceutical ingredients, so this route sits close to the start of many R&D programmes.
Beyond indoles, arylhydrazines of this type feed into indazoles, pyrazoles and related nitrogen heterocycles. Because the para-bromine survives the condensation step unchanged, the resulting scaffold can be further functionalised by Suzuki, Buchwald or related couplings without protecting-group gymnastics.
The product is used mainly in pharmaceutical process research and in the synthesis of specialty dye intermediates, where the hydrazone linkage provides the chromophore. Its well-defined salt form makes it easy to charge accurately by weight, which matters for reproducible scale-up.
4-Bromophenylhydrazine Hydrochloride is packed in 25 kg net fibre drums with a double polyethylene liner to protect the salt from moisture. The material is hygroscopic, so keep the liner sealed between dispensing operations and reseal promptly after sampling.
Store in a cool, dry and well-ventilated place, protected from light, heat and moisture, and separate from oxidising agents and strong bases. It is classified as a corrosive solid (UN 3261, Class 8, Packing Group II); use chemical-resistant gloves, eye protection and appropriate ventilation, and follow the handling instructions in the SDS. Standard lead time is approximately four weeks, confirmed by email at the time of order.
4-Bromophenylhydrazine Hydrochloride is supplied at ≥ 98.0 % (HPLC) as a white to off-white crystalline powder. Each batch is released against a full COA; a TDS and a GHS-compliant English SDS are available on request. The material is classified as a corrosive solid (UN 3261, Class 8, Packing Group II), so it ships in appropriately certified packaging with the corresponding transport documents; our team issues the paperwork needed for freight by air, sea or courier.
For an overview of what a robust supplier dossier should contain, see qualifying a new chemical supplier. Minimum order quantity is 1 kg, with scale-up from kilograms to multi-kilogram and pilot-plant quantities on request.
Tell us your required quantity and destination. Our sales team replies within 24 hours with pricing, lead time, and shipping options. COA and SDS available on request.
4-Bromophenylhydrazine Hydrochloride is the hydrochloride salt of p-bromophenylhydrazine, an arylhydrazine building block used in heterocyclic synthesis — most notably the Fischer indole synthesis. It is supplied by Qingdao Marram Chemical Co., Ltd. as a pharmaceutical intermediate at ≥ 98.0% purity.
Purity ≥ 98.0% (COA provided with every batch), molecular formula C6H8BrClN2, molecular weight 223.50 g/mol, melting point 220–230 °C (decomposition), appearance: off-white to light brown crystalline powder. Custom specifications can be discussed for bulk orders.
Yes. It is classified as UN 3261, corrosive (Class 8, Packing Group II). We ship it in certified dangerous-goods packaging with complete transport documents and a GHS-compliant English SDS. Please confirm import requirements on your side before ordering.
The minimum order quantity is 1 kg, with a typical lead time of approximately 4 weeks after order confirmation (dangerous-goods logistics included). Final MOQ, pricing, and lead time are confirmed by email before ordering.
Email chaijing@marramchem.cn or call +86-15930139955 with your quantity and destination. We respond within 24 hours. COA, TDS, and a GHS English SDS are available via the document request form on this page.
4-Fluoro-2-methyl-1-cyanobenzene
View Product →CAS 24065-33-65-Chloro-2-thiophenecarboxylic acid
View Product →CAS 629-82-3Dioctyl Ether; Caprylyl Ether
View Product →CAS 6920-22-5Hexane-1,2-diol
View Product →CAS 5343-92-0Pentane-1,2-diol
View Product →CAS 1680-31-5Dioctyl carbonate
View Product →