5-Chloro-2-thiophenecarboxylic acid
2-Chlorothiophene-5-carboxylic acid (CAS 24065-33-6) is a chlorinated thiophene carboxylic acid used as an intermediate in pharmaceutical and agrochemical synthesis. The carboxylic acid group allows direct conversion to acid chlorides, esters, and amides, while the chlorine atom provides a site for further substitution or coupling reactions.
Thiophene derivatives are among the most common heterocyclic motifs in modern drug discovery, appearing in numerous marketed APIs across therapeutic areas.
2-Chlorothiophene-5-carboxylic acid (CAS 24065-33-6, C5H3ClO2S) combines a thiophene ring with a carboxylic acid and a chlorine substituent. The acid group converts straightforwardly into acid chlorides, esters, amides and hydrazides, so it slots into amide-coupling and esterification steps using standard reagents and conditions.
The ring chlorine is a second, independent handle: it can be displaced or cross-coupled to install aryl, alkyl or heteroaryl groups, letting one starting material serve several different downstream scaffolds. Thiophene itself is one of the most common heterocyclic motifs in modern drug discovery, appearing in marketed APIs across several therapeutic areas.
Chlorinated thiophene carboxylic acids of this type are established intermediates on routes to factor Xa inhibitors and related cardiovascular APIs. The para-chlorine on the ring is the site used to attach the amide side chain that carries most of the pharmacophore.
The carboxylic acid couples cleanly to amines and alcohols using carbodiimides, HATU or via the acid chloride, which makes the compound convenient for building libraries of thiophene amides and esters during lead optimisation.
Thiophene carboxylic acids also appear in crop-protection chemistry and in specialty materials, where the sulfur heterocycle contributes to both biological activity and electronic properties. The chlorine offers a further point of variation for structure-activity work.
Alongside catalogue supply we offer custom synthesis and scale-up of thiophene and other sulfur heterocycle derivatives. Our process team develops a route from gram-scale feasibility through kilogram and pilot batches, controlling the impurity profile and the chlorination or carboxylation steps before transferring to commercial production.
Work in this area frequently covers substituted thiophene carboxylic acids, thiophene amides and esters, and ring-functionalised heterocycles for pharmaceutical or agrochemical programmes. If the exact derivative you need is not listed here, send the structure and the target quantity and we will respond with a feasibility assessment and indicative lead time.
2-Chlorothiophene-5-carboxylic acid is packed in 25 kg net drums with an inner liner, and smaller quantities are available for laboratory and process-development work.
Store in a cool, dry, well-ventilated place in tightly closed containers, protected from light and moisture and separated from strong oxidising agents and bases. Follow good industrial hygiene practice and use the protective equipment specified in the SDS when handling the powder. Standard lead time is approximately four weeks, confirmed by email at the time of order.
2-Chlorothiophene-5-carboxylic acid is supplied at ≥ 98.0 % (HPLC) as a white to off-white crystalline solid. Each batch is released with a COA; a TDS and a GHS-compliant English SDS are available on request. Minimum order quantity is 1 kg, and quantities from grams through multi-kilogram and pilot scale can be produced against an agreed specification.
For guidance on the supplier documentation worth reviewing before a scale-up, see qualifying a new chemical supplier.
Tell us your required quantity and destination. Our sales team replies within 24 hours with pricing, lead time, and shipping options. COA and SDS available on request.
2-Chlorothiophene-5-carboxylic acid, also known as 5-Chloro-2-thiophenecarboxylic acid, is a pharmaceutical intermediate (off-white powder, purity ≥ 98.0%). It is supplied by Qingdao Marram Chemical Co., Ltd. for pharmaceutical, agrochemical, and fine chemical applications.
Our 2-Chlorothiophene-5-carboxylic acid is available at ≥ 98.0% purity (COA provided with every batch), appearance: off-white powder. Molecular formula: C5H3ClO2S, molecular weight: 162.58 g/mol. Custom specifications can be discussed for bulk orders.
Yes — an English SDS for 2-Chlorothiophene-5-carboxylic acid can be requested by email at chaijing@marramchem.cn. We are preparing the downloadable version.
The minimum order quantity is 1 kg. Final MOQ and volume pricing are confirmed by email. 2-Chlorothiophene-5-carboxylic acid is produced and shipped with a typical lead time of approximately 4 weeks after order confirmation. Please confirm current availability and lead time by email before ordering. Larger quantities from kilograms to metric tons can be produced at our Lanzhou manufacturing base.
Email chaijing@marramchem.cn or call +86-15930139955 with your required quantity and destination. We respond within 24 hours with pricing, lead time, and shipping options (air, sea, or courier).
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